Drug Delivery

IBRAHIM, Hisham

Professor
Department of Biochemistry & Biotechnology
Faculty of Agriculture, Kagoshima University
Korimoto 1-21-24, Kagoshima 890-0065, JAPAN
Tel : +81 99-285-8658
Fax: +81 99-285-8525
E-mail: hishamri@chem.agri.kagoshima-u.ac.jp

Doctoral program: Biochemistry and Applied Biosciences
          (Applied Resource Chemistry)
Master program: Biologically Functional Foods & Nutraceuticals
           (Biochemical Sciences)
Undergraduate program: Biochemical Science and Technology

Food Biochemistry Laboratory
Research Interest
  Our research interests relate mainly to generation of new peptides therapy (Bio-peptides) from avian egg, human milk and Lactic acid bacteria (LAB) against infectious diseases, using genetic, molecular, and biochemical tools. The research has potential medical benefits beyond its primary goal of basic scientific understanding.



Bio-active Peptides Research
   (Biopeptides That Heal)
Biopeptides research
Antibiotic Resistance
Specific Interest:
  With a strong background in protein/peptide chemistry, I worked for a number of years into mechanisms of biodefense protein and peptides systems. We were the first to uncover the functional mysteries of several important proteins present in avian eggs and milk as a means of developing novel therapeutic and food applications. We could elucidate the molecular basis of the defense mechanism of lysozyme in human milk, thought to be involved in protection of infants against infectious diseases, and unravelled a hitherto molecular mechanistic link between proteolytic activity in infant stomach as well as by immune cells and the activation of lysozyme into a powerful defense molecule. In conjunction with genetic engineering, we could develope yeast expression systems for the research and therapeutic applications of bioactive peptides of human lysozyme which prevent infectious diseases. This work involved development of a sensitive assays to measure biological activities of recombinant peptides in biological fluids using cell-based systems and mass spectrometry.
  Other bioactive peptides, such as OTAP92 and RACOT, generated from ovotransferrin (OTf), were also discovered. The role of OTf peptides as mediators in destroying cancer cells and protection against oxidative stress is elucidated, and in a collaborative projects with food and cosmetics companies, food-derived peptides which have potential as anti-inflammatory and antimicrobial agents, have been explored. We are very much involved in innovative Biomedical Sciences at Kagoshima University, which runs in parallel with the functional food applications of bioactive peptides
.

Mining the Secrets of Bio-defense Peptides:
   Now we are exploring novel bio-peptides from new isolates of plant lactic acid bacteria (LAB) that are associated with yeast fermentation. The research led to the finding that LAB have many bio-peptides and bio-macromolecules which exert biological functions beyond expectation in the human gut. 

  Recent research interests relate mainly to infectious and neurodegenerative diseases. Current projects concerned with the development of novel drug-delivery strategy by utilizing physicochemical and biological properties of Lysozyme to specifically deliver water-insoluble antibiotics to the membrane of disease-causing bacteria (pathogens), with a view to explore a novel therapeutic potential of lysozyme for the treatment of infectious diseases.


Our Novel Drug-delivery Strategy by Utilizing Lysozyme
Antibiotic Resistance is a Growing Threat
Hisham Office

Published Papers
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